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The main difference between androgenic and anabolic is that androgenic steroids generate male sex hormone-related activity whereas anabolic steroids increase both muscle mass and the bone massof the skeletal musculature and are known to decrease bone resorption [38]; thus, the androgenic steroid effect is more pronounced. In addition, most commonly used anabolic steroids (i.e. testosterone ester and testosterone ethinyl estradiol) are highly anabolic drugs and have very little of an anabolic effect. Because anabolic steroids have been used for long time to stimulate anabolism and fat mass [39,40], the metabolic effect of these substances on skeletal muscle and bone becomes more important for their overall effects on body composition and bone mineral density [41]. It has been demonstrated that anabolic steroids have a significant effect on bone mass and inversely on the skeleton, whereas estrogenic steroids influence the skeleton [42-44]. For most of the anabolic steroid drugs, the skeletal response is mediated through various pathways, particularly the steroid hormone receptor protein, which is a member of the nuclear receptor family, which consists of four members, namely, receptor alpha, beta, gamma and delta, and the ligand-binding site [38]. In addition, the anabolic effects can be mediated by the estrogen receptor α. For more than 20 years, several studies have demonstrated that a variety of androgen receptor–like proteins [e.g. aromatase (Ariely and Lee, 2002-2004)) can be induced during the early postnatal period and that these proteins are responsible for the skeletal response to a variety of anabolic steroids with particular relevance for body composition changes [45]. Because these changes in the skeletal muscle and bone are important in regulating anabolic steroid hormonal and metabolic activities, the interaction of these substances could have a profound effect on bone health. The influence of different anabolic and androgenic steroids on the metabolism of different tissues and organ systems have been studied in different models. For example, high-dose oral androgenic steroids decrease skeletal muscle mass during early adulthood (Pfeiffer et al. 2003; O’Neill et al. 2003). However, in comparison to the androgenic steroid effect, the increase in muscle mass with androgenic steroid treatment is greater (Pfeiffer et al. 2003). High-dose oral anabolic steroids decrease the skeletal muscle mass in adult humans (Kunz et al. 2003), whereas high-dose androgenic steroid treatment increases skeletal muscle mass (Pfeiffer et al. 2003). In animal models, there also exists a negative influence of the anabolic steroid hormones on skeletal muscle and bone metabolism. When

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These legal steroids are great alternatives to the illegal anabolic types. They have no side effects and they work too. — the options for steroid alternatives systems. Also, clenbuterol is not a true anabolic steroid, instead, it is a stimulant. Athletes and professional weightlifters frequently use these supplements to increase the rate of their muscle growth. Natural alternatives to anabolic steroids

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